Video

Dr. Choudhury on the Different States of Nonmetastatic CRPC

Atish D. Choudhury, MD, PhD, discusses the different states of nonmetastatic castration-resistant prostate cancer.

Atish D. Choudhury, MD, PhD, co-director of the Prostate Cancer Center, senior physician, Dana-Farber Cancer Institute, instructor in medicine, Harvard Medical School, discusses the different states of nonmetastatic castration-resistant prostate cancer (CRPC).

Nonmetastatic CRPC represents a diffuse set of ​disease states, says Choudhury. ​Although this cancer is castration resistant, the location of the disease can vary.

For example, in some patients it represents local recurrence while, in others, it represents recurrence with pelvic lymph node involvement​, explains Choudhury.

Furthermore, ​nonmetastatic CRPC could consist of micrometastatic disease that may or may not be detectable on novel imaging​, Choudhury says. Notably, all of these states were included in 3 pivotal phase 3 trials in the space: PROSPER, SPARTAN, and ARAMIS.

Ultimately, in terms of disease management, the agents evaluated in these studies are of critical importance. ​Novel imaging and focal therapy may also play a role as well, Choudhury concludes.

Related Videos
Craig Eckfeldt, MD, PhD, assistant professor, medicine, faculty, Microbiology, Immunology, and Cancer Biology PhD Graduate Program, Division of Hematology, Oncology, and Transplantation, the University of Minnesota Medical School
Marc Machaalani, MD
Alicia Morgans, MD, MPH, genitourinary medical oncologist, medical director, Survivorship Program, Dana-Farber Cancer Institute; associate professor, medicine, Harvard Medical School
Alfred L. Garfall, MD, MS
Razane El Hajj Chehade, MD
Mark Juckett, MD, professor, medicine, Division of Hematology, Oncology, and Transplantation, the University of Minnesota Medical School
Coral Olazagasti, MD
Barbara Jane O’Brien, MD, associate professor, Neuro-Oncology, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
Tycel Phillips, MD
Giuseppe Curigliano, MD, PhD