Commentary

Video

Dr. Conlin on the Benefits of Trastuzumab Deruxtecan in HER2-Low Breast Cancer

Alison K. Conlin, MD, discusses the benefits of trastuzumab deruxtecan in HER2-low breast cancer.

Alison K. Conlin, MD, medical oncology, Providence Cancer Institute Franz Clinic, discusses the benefits of fam-trastuzumab deruxtecan-nxki (Enhertu) in HER2-low breast cancer. 

The phase 3 DESTINY-Breast04 trial (NCT03734029) evaluated the safety and efficacy of the antibody-drug conjugate (ADC) trastuzumab deruxtecan vs physician’s choice therapy as second-line therapy in patients with HER2-low breast cancer.

The results showed that the ADC should be used in the second-line setting, Conlin says. Although there are many treatments available, trastuzumab deruxtecan is a great option with a high rate of survival, Conlin explains.

Moreover, the duration of response is prolonged with the agent, Conlin continues. As such, this offers patients more time to receive subsequent therapies, Conlin concludes.

Related Videos
Funda Meric-Bernstam, MD
Bhavana Pothuri, MD
Kristen Spencer, DO
Laurence Albigès, MD, PhD
Nirav Shah, MD, MSHP, discusses evaluating zamtocabtagene autoleucel in patients with relapsed/refractory diffuse large B-cell lymphoma.
Bhagirathbhai Dholaria, MBBS
Sairah Ahmed, M.D
Joshua K. Sabari, MD
Barry W. Goy, MD
Fred Saad, CQ, MD, FRCS, FCAHS, director, Prostate Cancer Research, Montreal Cancer Institute, Centre Hospitalier de l’Université de Montréal; full professor, Department of Surgery, Université de Montréal; uro-oncologist, Urology Department, University of Montreal Health Center