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Commentary|Videos|December 10, 2025

Dr Kamdar on the Long-Term Efficacy of Liso-Cel in R/R LBCL

Fact checked by: Ashling Wahner , Chris Ryan

Manali Kamdar, MD, discusses the long-term efficacy findings with lisocabtagene maraleucel in patients with relapsed/refractory large B-cell lymphoma.

“Looking at the outcome data and the entire overall survival [OS] for the TRANSFORM [trial] and the long-term follow-up cohort, the median OS was not reached, with a 48-month OS [rate] of [61.5]% in the liso-cel–treated patients.”

Manali Kamdar, MD, an associate professor of medicine-hematology in the Division of Hematology at the University of Colorado and clinical director of Lymphoma Services at the UCHealth Blood Disorders and Cell Therapies Center—Anschutz Medical Campus and the University of Colorado Cancer Center, discussed long-term follow-up findings from the phase 3 TRANSFORM trial (NCT03575351) investigating lisocabtagene maraleucel (liso-cel; Breyanzi) in patients with second-line relapsed/refractory large B-cell lymphoma.

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