Dr. Kumar on Ongoing Research in Multiple Myeloma

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Conference|Charlotte Plasma Cell Disorder Congress

Shaji K. Kumar, MD, professor of medicine, Mayo Clinic, discusses ongoing research in multiple myeloma.

Shaji K. Kumar, MD, professor of medicine, Mayo Clinic, discusses ongoing research in multiple myeloma.

The use of minimal residual disease (MRD) could lead to personalized treatment strategies in multiple myeloma, says Kumar. Currently, clinical trials are, in addition to evaluating novel combination regimens, incorporating MRD negativity status to guide individualized treatment approaches and schedules.

For example, in the phase III AURIGA trial, patients who are MRD positive following autologous stem cell transplant will be randomized to maintenance therapy with the combination of daratumumab (Darzalex) plus lenalidomide (Revlimid) versus lenalidomide alone to determine the optimal duration of maintenance therapy and the need for an CD38 antibody. Moreover, in the relapsed/refractory setting, genomics could take on a greater role in guiding individualized treatment decisions, concludes Kumar.

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Sundar Jagannath, MBBS, director, Center of Excellence for Multiple Myeloma, professor of medicine (hematology and medical oncology), The Tisch Cancer Institute, Mount Sinai
Omid Hamid, MD, professor, medicine, Cedars-Sinai; director, Clinical Research and Immunotherapy, director, Cutaneous Oncology and Melanoma, The Angeles Clinic and Research Institute
Christina L. Roland, MD, MS, FACS
Ashish Saxena, MD, PhD
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Scott Kopetz, MD, PhD, FACP
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Catherine C. Coombs, MD, associate clinical professor, medicine, University of California, Irvine School of Medicine
Naomi Adjei, MD, MPH, MSEd, gynecologic oncology fellow, The University of Texas MD Anderson Cancer Center
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