Video

Dr. Shapiro Discusses Bosutinib in CML

Mark Shapiro, MD, PhD, discusses bosutinib as treatment for patients with CML.

Mark Shapiro, MD, PhD, Global Medical Affairs Lead, Hematology Programs, Pfizer, discusses bosutinib as treatment for patients with CML.

Shapiro says bosutinib is the fourth TKI to be approved for the treatment of CML. The mechanism of action of bosutinib is similar to other TKIs, Shapiro says, but there are some fundamental differences. Bosutinib targets the BCR-ABL kinase and inhibits the Src kinase.

Shapiro says the most significant difference among the compounds is their tolerability profile. Each of these compounds has their own set of adverse events.

Subsequent to the approval of bosutinib was ponatinib, Shapiro says, which was recently temporarily withdrawn from the market in the United States.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity