Dr. Trent on the Role of Avapritinib in PDGFRA Exon 18+ GIST

Video

In Partnership With:

Jonathan C. Trent, MD, PhD, discusses the role of avapritinib in PDGFRA exon 18–positive gastrointestinal stromal tumor.

Jonathan C. Trent, MD, PhD, professor and associate director for Clinical Research at the Sylvester Comprehensive Cancer Center, University of Miami Health System, discusses the role of avapritinib (Ayvakit) in PDGFRA exon 18–positive gastrointestinal stromal tumor (GIST).

In January 2020, the FDA approved avapritinib for the treatment of adult patients with unresectable or metastatic GIST who harbor a PDGFRA exon 18 mutation, including PDGFRA D842V mutations.

Prior to the approval, findings from the randomized phase 3 VOYAGER trial failed to demonstrate a survival benefit with avapritinib vs regorafenib (Stivarga) in patients with locally advanced, unresectable or metastatic GIST. However, data from the phase 1 NAVIGATOR study showed an 84% overall response rate with avapritinib in patients with PDGFRA exon 18–mutant GIST.

PDGFRA exon 18–mutant GIST is resistant to all other available TKIs for patients with GIST, so the approval of avapritinib filled a significant unmet need for this specific patient population, says Trent. Moreover, the efficacy demonstrated with avapritinib was similar to that demonstrated with imatinib (Gleevec) in patients with KIT-mutant GIST, concludes Trent.

Related Videos
Jeffrey Zonder, MD
Jun Gong, MD
John Michael Bryant, MD,
Chandler H. Park, MD, FACP
Kathryn Beckermann, MD, PhD
Eleonora Dondossola, PhD
William B. Pearse, MD
Pasi A. Jänne, MD, PhD, director, Lowe Center for Thoracic Oncology, director, Belfer Center for Applied Cancer Science, director, Chen-Huang Center for EGFR Mutant Lung Cancers, senior physician, David M. Livingston, MD, Chair, Dana-Farber Cancer Institute; professor, medicine, Harvard Medical School
Rachid Baz, MD, section head, Myeloma, Department of Malignant Hematology, Moffitt Cancer Center; co-director, Pentecost Family Myeloma Research Center
Harriet Kluger, MD, Harvey and Kate Cushing Professor of Medicine (Oncology) and of Dermatology; director, Yale SPORE in Skin Cancer; vice chair, Translational Research, Internal Medicine; chief, Division of Skin and Kidney Cancer; associate cancer center director, Education, Training and Faculty Development; deputy section chief, Medical Oncology, Yale Cancer Center