Dr. Debu Tripathy from USC Norris Comprehensive Cancer Center Discusses Iniparib Trial Heterogeneity
Debu Tripathy, MD, professor of medicine and co-leader of the Women’s Cancer Program at the University of Southern California Norris Comprehensive Cancer Center, discusses the differences in survival among studies on iniparib in as a first-, second-, and third-line treatment.
The phase II trial showed a marked difference in survival and disease-free survival, but subsequent studies did not show that with first-line patients. In second- and third-line patients, however, the treatment was effective.
The differences in the trial results have led to discussions regarding tumor heterogeneity and how that heterogeneity might affect a population of patients rather than one particular tumor. In this case, the first-line patients might be different than the second- and third-line patients when it comes to their tumors. Tissue samples are being studied to determine what might be causing this heterogeneity.