Video

Dr. Venook on Immunotherapy Potential in Colorectal Cancer

Alan P. Venook, MD, The Madden Family Distinguished Professor of Medical Oncology and Translational Research at the University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, discusses the potential that immunotherapy may have in the treatment of patients with colorectal cancer.

Alan P. Venook, MD, The Madden Family Distinguished Professor of Medical Oncology and Translational Research at the University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, discusses the potential that immunotherapy may have in the treatment of patients with colorectal cancer (CRC).

Venook describes a subtype of CRC, referred to as subtype 4, which tends to have tumors with heavy lymphocytic infiltrate, and could therefore derive benefit from immunotherapy agents. However, evidence suggests that microsatellite instability (MSI)­—high patients with metastatic disease can benefit from checkpoint inhibitors. Moreover, this is only about 3% to 4% of patients with metastatic disease, says Venook.

In terms of the future that checkpoint inhibitors may have in this treatment landscape, Venook mentions some recent data that suggest the possibility to “fake” cancers out, and make them behave as if they are MSI-high. A randomized study is looking at the combination of a MEK inhibitor plus a checkpoint inhibitor to see whether that treatment could flip the cancer to behave similar to MSI-high, though those results remain to be seen.

Related Videos
Fred Saad, CQ, MD, FRCS, FCAHS
Eric Kumar Singhi, MD
Seth Wander, MD, PhD
Lillian L. Siu, MD, FRCPC
Marc Machaalani, MD
Mark Awad, MD, PhD, chief, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center
Rasha Cosman, BSc, MBBS, FRACP
Saad Z. Usmani, MD, MBA, FACP, FASCO
Nicholas P. McAndrew, MD, MSCE
Xichun Hu, MD, PhD