Dr. Yorio on T-DM1 in HER2-Mutant Lung Cancer Treatment

Video

Jeff Yorio, MD, discusses a small phase II study that is looking at using ado-trastuzumab emtansine to treat patients with HER2-mutant metastatic lung cancer.

Jeff Yorio, MD, medical oncologist, Texas Oncology, discusses a small phase II study that is looking at using ado-trastuzumab emtansine (T-DM1; Kadcyla) to treat patients with HER2-mutant metastatic lung cancer.

Patients involved in the study were heavily pretreated with traditional treatments for metastatic lung cancer, including chemotherapy and immunotherapy. The partial response rate to ado-trastuzumab emtansine in this study was 44% and stable disease was observed in 39% of patients.

Ado-trastuzumab emtansine is not yet approved for use in lung cancer; however, the National Comprehensive Cancer Network is recommending the drug for HER2-mutant patients with metastatic lung cancer.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Minesh Mehta, MD
Ruben Olivares, MD
Phillip J. Koo, MD