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Commentary|Videos|July 23, 2025

Factors for Selecting Iptacopan in C5 Inhibitor–Naive and –Exposed PNH

Author(s)Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, David Dingli, MD, PhD

Fact checked by: Chris Ryan

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, detail factors for selecting iptacopan in C5 inhibitor–naive and –exposed PNH.

Episodes in this series

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, on the current management of paroxysmal nocturnal hemoglobinuria.

EP. 1 Reviewing Current Standards in Paroxysmal Nocturnal Hemoglobinuria

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, discuss the role of C5 inhibitors in the management of paroxysmal nocturnal hemoglobinuria.

EP. 2 Role of C5 Inhibitors in the Management of Paroxysmal Nocturnal Hemoglobinuria

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, on the implications of the FDA approval of Iptacopan for PNH.

EP. 3 Implications of the FDA Approval of Iptacopan for PNH

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, on data for iptacopan in PNH after switching anti-C5 therapy.

EP. 4 Data for Iptacopan in PNH After Switching Anti-C5 Therapy: The APPULSE-PNH Trial

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, detail factors for selecting iptacopan in C5 inhibitor–naive and –exposed PNH.

EP. 5 Factors for Selecting Iptacopan in C5 Inhibitor–Naive and –Exposed PNH

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, discuss implications of data from the APPULSE-PNH trial of iptacopan.

EP. 6 Implications of APPULSE-PNH Data for Iptacopan in PNH

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, discuss unmet needs to address in the management of PNH.

EP. 7 Addressing Further Unmet Needs in PNH

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