FDA Approval Insights: Momelotinib in Myelofibrosis With Anemia


Dr Kuykendall discusses the FDA approval of momelotinib in myelofibrosis with anemia, key data from the MOMENTUM trial, and how momelotinib alters the myelofibrosis treatment paradigm.

Welcome to OncLive On Air®! I’m your host today, Ashling Wahner.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored by GSK, we had the pleasure of speaking with Andrew Kuykendall, MD, about the FDA approval of momelotinib in myelofibrosis with anemia. Dr Kuykendall is an assistant member in the Department of Malignant Hematology at Moffitt Cancer Center in Tampa, Florida.

On September 15, 2023, the FDA approved momelotinib for the treatment of adult patients with intermediate- or high-risk myelofibrosis with anemia. This regulatory decision was backed by findings from the phase 3 MOMENTUM trial (NCT04173494). In MOMENTUM, 25% of patients who received momelotinib achieved a Myelofibrosis Symptom Assessment Form v4.0 total symptom score reduction of at least 50% vs 9% of patients who received danazol.

In our exclusive interview, Dr Kuykendall discussed the significance of this approval, key data from MOMENTUM, and how momelotinib alters the myelofibrosis treatment paradigm.


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