First-Line Dasatinib in Chronic Myeloid Leukemia

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In the randomized DASISION trial, first-line imatinib was compared with dasatinib 100 mg once daily in patients with early chronic phase chronic myeloid leukemia (CML). Dasatinib demonstrated superiority based on the analyses of the primary endpoint of confirmed complete cytogenetic response (CCyR) within 12 months, and relevant secondary endpoints, Elias Jabbour, MD, describes.

Four-year follow-up data from DASISION showed that the superiority was maintained throughout the study period with deeper and faster responses. The major molecular response with dasatinib was 76% compared with 63% with imatinib. An optimal molecular response at 3 months was 84% with dasatinib versus 64% with imatinib. Once a patient achieves a deep response, the dose can be aggressively reduced, Neil Pravin Shah, MD, states. Additionally, brief drug interruptions can be utilized if side effects are troubling.