
|Videos|January 31, 2019
First-Line Triplet in BRAF+ mCRC
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Episodes in this series

An overview of the goals and design of the phase II single arm ANCHOR trial, which looks at the combination triplet regimen used in the BEACON study, encorafenib, binimetinib, and cetuximab, as first-line treatment for BRAFV600E-mutant metastatic colorectal cancer (mCRC).
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Read a refresh of GI cancer FDA news from July 2026, including an NDA acceptance for a RAS(ON) inhibitor in pancreatic cancer.

Neeta Somaiah, MD, discusses the significance of the Peak study and what an approval of bezuclastinib plus sunitinib would mean for GIST.

ASCO’s ctDNA guidelines support testing for genetic alterations in select scenarios but do not endorse it for residual disease or recurrence monitoring.

Updated ASCO Living Guideline recommendations expand frontline therapy for HER2-positive gastroesophageal cancer to include zanidatamab-based regimens.

Paul E. Oberstein, MD, discusses autogene cevumeran, a personalized mRNA vaccine, which is being evaluated for pancreatic ductal adenocarcinoma.

Following the RASolute 302 readout, ESMO now endorses daraxonrasib after chemotherapy progression in RAS-mutated metastatic pancreatic cancer.
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