HER2-Positive Early Breast Cancer: Multidisciplinary Coordination in Adjuvant Care

Dr. Neil Iyengar concludes the case-based discussion by exploring the role of multidisciplinary care in the management of HER2-positive early breast cancer following neoadjuvant therapy. Dr. Kelly McCann and Dr. Alison Conlin discuss practical considerations for coordinating adjuvant systemic therapy with radiation therapy in patients receiving trastuzumab deruxtecan-based treatment. The faculty review available clinical evidence supporting concurrent or sequential radiation approaches and emphasize the importance of collaboration among medical oncologists, radiation oncologists, and surgical teams to ensure timely and effective care for patients at high risk of recurrence. They also consider how multidisciplinary communication can help optimize treatment sequencing while maintaining patient safety and minimizing delays in therapy. The discussion highlights the importance of individualized treatment planning and coordinated decision-making as emerging evidence continues to shape the management of HER2-positive early breast cancer in the curative-intent setting.