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Commentary|Articles|October 7, 2025

How Cemiplimab Plus Chemo Has Affected First-Line NSCLC Management, Including Squamous Histology

Author(s)Eric K. Singhi, MD, Sandip P. Patel, MD

Fact checked by: Chris Ryan

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss the impact of the FDA approval of cemiplimab plus chemotherapy in advanced NSCLC.

Episodes in this series

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss treatment and sequencing considerations in advanced non–small cell lung cancer.

EP. 1 Treatment Decision-Making and Sequencing Factors in Advanced Non–Small Cell Lung Cancer

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss the impact of the FDA approval of cemiplimab plus chemotherapy in advanced NSCLC.

EP. 2 How Cemiplimab Plus Chemo Has Affected First-Line NSCLC Management, Including Squamous Histology

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss the management of immune-related adverse effects in advanced NSCLC.

EP. 3 Managing Immune-Related AEs in NSCLC

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss 5-year data for cemiplimab plus chemotherapy in advanced NSCLC.

EP. 4 5-Year EMPOWER-Lung 3 Data for Cemiplimab Plus Chemo in Advanced NSCLC

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss the use of immunotherapy after prior immunotherapy for early-stage NSCLC.

EP. 5 Navigating Immunotherapy in Advanced NSCLC After Early-Stage IO Therapy

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss key data from the 2025 World Conference on Lung Cancer.

EP. 6 Eye-Catching Data From the 2025 World Conference on Lung Cancer

Eric K. Singhi, MD, and Sandip P. Patel, MD, discuss future areas of research and unmet needs in non–small cell lung cancer.

EP. 7 Future Avenues of Research in Advanced NSCLC

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