Introduction: Understanding ALL and Its Prognostic Factors

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Moderator Leonard S. Sender, MD, clinical professor of medicine at the School of Medicine University of California, Irvine, facilitates a discussion about the key prognostic factors in Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). Mark R. Litzow, MD, professor of medicine at the College of Medicine, Mayo Clinic in Rochester, Minnesota, lists some of the more commonly recognized prognostic factors, including age and cytogenetics. In addition, Litzow touches on the use of minimal residual disease (MRD) and various genetic mutations as emerging prognostic tools.