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Commentary|Videos|October 15, 2025

Navigating Second-Line Treatment Decisions in Lower-Risk MDS

Author(s)Guillermo Garcia-Manero, MD

Fact checked by: Chris Ryan

Guillermo Garcia-Manero, MD, discusses second-line treatment decision-making in lower-risk MDS.

Episodes in this series

Guillermo Garcia-Manero, MD, highlights recent shifts in the lower-risk myelodysplastic syndrome treatment paradigm.

EP. 1 Recent Shifts in the Management of Lower-Risk MDS

Guillermo Garcia-Manero, MD, discusses OS data from the COMMANDS trial for luspatercept in ESA-naive, lower-risk MDS.

EP. 2 OS Data From COMMANDS for Luspatercept in ESA-Naive, Lower-Risk MDS

Guillermo Garcia-Manero, MD, highlights clinical trial findings and real-world data for luspatercept in ESA-naive, lower-risk MDS.

EP. 3 How Data Are Defining the Role of Luspatercept in ESA-Naive, Lower-Risk MDS

Guillermo Garcia-Manero, MD, discusses the integration of luspatercept into real-world practice in ESA-naive, lower-risk MDS.

EP. 4 Integrating Luspatercept Into Clinical Practice and Community Settings in ESA-Naive Lower-Risk MDS

Guillermo Garcia-Manero, MD, discusses second-line treatment decision-making in lower-risk MDS.

EP. 5 Navigating Second-Line Treatment Decisions in Lower-Risk MDS

Guillermo Garcia-Manero, MD, discusses ongoing research to watch in MDS.

EP. 6 Key Areas of Ongoing Research in MDS

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