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A new drug application (NDA) has been submitted to the FDA seeking the approval of savolitinib (Orpathys) plus osimertinib (Tagrisso) for patients with locally advanced or metastatic, EGFR-mutated non–small cell lung cancer (NSCLC) with MET overexpression or amplification following progression on EGFR TKI therapy, supported by data from the phase 3 SAFFRON trial (NCT05261399). Approximately what proportion of tumors develop high MET overexpression or amplification after progression on third-generation EGFR TKIs?





