
Opinion|Videos|November 19, 2025
Ongoing Research to Watch in TNBC
Panelists spotlight key trials and drugs to watch in ongoing research in triple-negative breast cancer.
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The panel concludes by highlighting pivotal ongoing trials and investigational agents shaping the future of TNBC care. Areas of focus include next-generation ADCs, bispecific antibodies, and novel immunotherapy combinations designed to overcome resistance. Panelists also underscore the need for improved biomarker discovery, especially to identify which patients benefit most from immunotherapy or ADC-based regimens. They note that the TNBC research field is entering a dynamic phase where rational combination strategies and earlier intervention with effective agents could significantly improve patient outcomes.
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The filing is supported by phase 3 REZILIENT3 data showing a median PFS of 14.5 vs 8.5 months with zipalertinib plus chemotherapy vs chemotherapy.

A European Commission decision on belzutifan plus lenvatinib in pretreated advanced ccRCC is expected within 2 months, based on LITESPARK-011 data.

The phase 3 4WARD trial is evaluating mavorixafor for reducing infection rates and raising neutrophil counts in patients with primary chronic neutropenia.

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Age, geographic location, transportation barriers, and language and communication barriers may limit patient opportunities to participate in research.

Targeting two alternate pathways at the same time led to improved outcomes in multiple preclinical models of advanced breast cancer.

Updated LEGEND cohort 1 data showed a 56% CR rate and a 24% 12-month CR rate with detalimogene in BCG-unresponsive, high-risk NMIBC with CIS.
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