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Opinion|Videos|November 19, 2025

Ongoing Research to Watch in TNBC

Author(s)Neil M. Iyengar, MD, Kevin Kalinsky, MD, Virginia Borges, MD

Panelists spotlight key trials and drugs to watch in ongoing research in triple-negative breast cancer.

Episodes in this series

EP. 1 Current Frontline Treatment Approaches and Challenges in Advanced TNBC

EP. 1 Current Frontline Treatment Approaches and Challenges in Advanced TNBC

EP. 2 Contextualizing Data for Frontline Sacituzumab Govitecan Plus Pembrolizumab in PD-L1+ TNBC

EP. 2 Contextualizing Data for Frontline Sacituzumab Govitecan Plus Pembrolizumab in PD-L1+ TNBC

EP. 3 ASCENT-03: Data for Frontline Sacituzumab Govitecan in IO-Ineligible TNBC

EP. 3 ASCENT-03: Data for Frontline Sacituzumab Govitecan in IO-Ineligible TNBC

EP. 4 Safety Profile of Sacituzumab Govitecan–Based Treatment in Frontline TNBC

EP. 5 Addressing Sequencing Questions With TROP-2–Directed ADCs in TNBC

EP. 5 Addressing Sequencing Questions With TROP-2–Directed ADCs in TNBC

EP. 6 Findings for Frontline Dato-DXd From TROPION-Breast02 in Immunotherapy-Ineligible TNBC

EP. 6 Findings for Frontline Dato-DXd From TROPION-Breast02 in Immunotherapy-Ineligible TNBC

EP. 7 Highlighting Additional Key TNBC Data From ESMO 2025

EP. 7 Highlighting Additional Key TNBC Data From ESMO 2025

EP. 8 Ongoing Research to Watch in TNBC

EP. 8 Ongoing Research to Watch in TNBC

The panel concludes by highlighting pivotal ongoing trials and investigational agents shaping the future of TNBC care. Areas of focus include next-generation ADCs, bispecific antibodies, and novel immunotherapy combinations designed to overcome resistance. Panelists also underscore the need for improved biomarker discovery, especially to identify which patients benefit most from immunotherapy or ADC-based regimens. They note that the TNBC research field is entering a dynamic phase where rational combination strategies and earlier intervention with effective agents could significantly improve patient outcomes.

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