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Commentary|Videos|October 28, 2024

Preclinical CNS Data for Zidesamtinib and Other ROS1 Inhibitors

Author(s)Benjamin Besse, MD, Gregory J. Riely, MD, PhD

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.

Episodes in this series

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss testing for ALK-positive and ROS1-positive non–small cell lung cancer.

EP. 1 Testing for ALK Fusions and ROS1 Rearrangements in NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for NVL-655 in ALK-positive NSCLC and other ALK-positive solid tumors.

EP. 2 Data for NVL-655 in Advanced ALK+ NSCLC and Solid Tumors from the ALKOVE-1 Trial

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for zidesamtinib in ROS1-positive non–small cell lung cancer.

EP. 3 Findings for Zidesamtinib in Advanced ROS1+ NSCLC and Other Solid Tumors

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.

EP. 4 Preclinical CNS Data for Zidesamtinib and Other ROS1 Inhibitors

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.

EP. 5 Progression Patterns and Subsequent Therapies after Lorlatinib in ALK+ NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.

EP. 6 The TRUST-II Study of Taletrectinib in ROS1+ Advanced NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.

EP. 7 Lorlatinib in ROS1+ Advanced NSCLC After Crizotinib and Chemotherapy

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss unmet needs and future research directions in ALK-positive and ROS1-positive NSCLC.

EP. 8 Future Research Directions in ALK+ and ROS1+ NSCLC

Clinicians referring a patient to MSK can do so by visiting msk.org/refer, emailing [email protected], or by calling 833-315-2722.

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