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Preclinical cytotoxicity was demonstrated with anti-CD38-CAR-gamma-delta T cells in multiple myeloma.

Anti-CD38-CAR-γδ T Cells Show Preclinical Cytotoxicity in Myeloma

MT-8421, a novel engineered toxin body targeting CTLA-4, was not associated with grade 4 or 5 toxicities in patients with select advanced solid tumors.

MT-8421 Displays Acceptable Safety Profile in First-in-Human Trial for Advanced Solid Tumors

SAR444200-mediated targeting of GPC3-expressing solid tumors was safe and showed early signs of antitumor activity in a phase 1/2 study. 

SAR444200 Demonstrates Safety, Signals of Clinical Activity in Advanced GPC3+ HCC, Other Solid Tumors

The feasibility and safety of treatment with SAR443216 support the further investigation of this agent in patients with advanced HER2-positive tumors.

SAR443216 Engages HER2 With Manageable Toxicity in Advanced HER2+ Solid Tumors

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Patients with relapsed/refractory MCL who opted for elective treatment interruptions from venetoclax/ibrutinib experienced durable responses. 

7-Year Data Show Feasibility of Elective Treatment Interruption of Venetoclax/Ibrutinib in R/R MCL 

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as well as news and conference updates for OncLive.com. Email: kdoherty@mjhlifesciences.com

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™. She joined the company in 2018 as an assistant editor, with expertise in video production and print/digital publication. Email: cseymour@onclive.com​ 

Retifanlimab demonstrated durable activity with a tolerable safety profile in patients with chemotherapy-naive MCC.

Retifanlimab Adds FDA-Approved Option to Merkel Cell Carcinoma Treatment Landscape

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Megan Melody, MD, discusses how embracing authenticity, building patient trust, and supporting fellow female oncologists are key to thriving in the field.

Embracing Authenticity and Fostering Community Are Essential for Empowering Women in Oncology

A discovery by researchers from Mayo Clinic may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.

Mayo Clinic Researchers Identify Proteins Linked to Immunotherapy Resistance in Metastatic Colorectal Cancer

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Advances in the Treatment and Management of Myelodysplastic Syndrome (MDS): The Role of Oral HMAs

Real-World Use for Oral HMAs

Videos

Join Dr. Guillermo Garcia-Manero in this OncLive Insights program as he delves into the latest advancements in the treatment of myelodysplastic syndrome (MDS), with a specific focus on the emerging role of oral hypomethylating agents (HMAs).

This page is funded by Taiho Oncology, Inc. The faculty and publisher are solely responsible for this content. Taiho does not recommend or endorse the use of its products other than as described in the approved labeling. The content of this page is not medical advice and does not replace independent medical judgment.

Join Dr. Guillermo Garcia-Manero in this OncLive Insights program as he delves into the latest advancements in the treatment of myelodysplastic syndrome (MDS), with a specific focus on the emerging role of oral hypomethylating agents (HMAs). In this episode, gain insights about MDS risk stratification and prognosis, and why it is important to treat early.

Diagnosing and Managing Myelodysplastic Syndrome

The role of HMAs in the treatment of patients with intermediate- and high-risk MDS.

Treating Intermediate- and High-Risk MDS

Guillermo Garcia-Manero, MD, provides a high-level overview of the effectiveness of oral HMA agents in the treatment of intermediate- and high-risk MDS.

Available and Emerging Oral HMAs

An expert discusses the real-world impact of hypomethylating agents for the treatment of patients with MDS.

A review of the benefits of oral HMA treatments in the management of MDS, and the impact on a patient's quality of life.

The Impact of Oral HMA Treatment Options on QOL

An expert discusses data supporting the use of HMAs in the treatment of lower-risk MDS.

The Role for HMAs in Lower-Risk MDS

An overview of how HMAs are being used to treat CMML and their use in combination with other therapies for patients with AML.

Treating CMML and AML with HMAs

Guillermo Garcia-Manero, MD, reviews potential serious and common adverse effects associated with HMA treatments, shares tips for patient education to help manage these AEs, and discusses if and when a dose reduction or discontinuation may be necessary.

Real-World Use for Oral HMAs

EP: 1.Diagnosing and Managing Myelodysplastic Syndrome

EP: 2.Treating Intermediate- and High-Risk MDS

EP: 3.Available and Emerging Oral HMAs

EP: 4.Real-World Use for Oral HMAs

EP: 5.The Impact of Oral HMA Treatment Options on QOL

EP: 6.The Role for HMAs in Lower-Risk MDS

EP: 7.Treating CMML and AML with HMAs

EP: 8.Managing AEs Associated with HMA Treatment

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