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|Videos|January 24, 2022

SABCS 2021: Updates in Metastatic Breast Cancer

Author(s)Virginia G. Kaklamani, MD, DSc, Anne P. O’Dea, MD, Yara Abdou, MD

Expert panelists share their perspectives on metastatic breast cancer management datasets from the SABCS 2021 Virtual Meeting.

Episodes in this series

Expert on Breast Cancer

EP. 1 Coming Soon, HER2-Positive Breast Cancer: A Review of Data from the SABCS 2021 Virtual Meeting

Experts on Breast Cancer

EP. 2 SABCS 2021: Updates in Metastatic Breast Cancer

Experts on Breast Cancer

EP. 3 SABCS 2021: Brain Metastases Updates in Breast Cancer

Experts on Breast Cancer

EP. 4 SABCS 2021: Novel Approaches to Breast Cancer Management

Data from the following clinical trials are discussed:

GS3-01: Trastuzumab deruxtecan (T-DXd; DS-8201a) vs trastuzumab emtansine (T-DM1) in patients with HER2–positive metastatic breast cancer: subgroup analyses from the randomized phase 3 study DESTINYBreast03
GS3-02: Updated overall survival (OS) results from the phase 3 PHOEBE trial pyrotinib vs lapatinib in combination with capecitabine in patients with HER2+ metastatic breast cancer
GS4-10: Neratinib + fulvestrant + trastuzumab for hormone receptor (HR)–positive, HER2-mutant metastatic breast cancer and neratinib + trastuzumab for triple-negative disease: latest updates from the SUMMIT trial
P2-13-10: First-in-human HER2-targeted bispecific antibody KN026 for the treatment of patients with HER2+ metastatic breast cancer: results from a phase I study
P2-13-07: Zanidatamab (ZW25), a HER2-targeted bispecific antibody, in combination with chemotherapy for HER2+ breast cancer: results from a phase 1 study
PD8-07: Evaluation of tucatinib + paclitaxel + pertuzumab + trastuzumab followed by AC (doxorubicin hydrochloride, cyclophosphamide) in high-risk HER2+ stage II/III breast cancer: results from the I-SPY2 trial

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