Sauter and Hill Talk Through CAR T-Cell Sequencing and Access in Lymphomas

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Drs Sauter and Hill discuss the use of CAR T-cell therapy in patients with lymphomas, the potential for allogeneic CAR T cells, and ways to expand access and address financial toxicity.

Welcome to OncLive On Air®! I’m your host today, Jason Harris.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we spoke with Craig Sauter, MD, director of Cleveland Clinic’s Blood and Marrow Transplant Program, and Brian T. Hill, MD, PhD, director of the Lymphoid Malignancies Program and a staff physician at the Cleveland Clinic Taussig Cancer Institute, about the use of CAR T-cell therapy in patients with lymphomas.

Drs Sauter and Hill discussed the findings from the phase 3 ZUMA-7 (NCT03391466) and TRANSFORM (NCT03575351) trials, which suggest that CAR T cells might be more effective in the second-line setting compared with standard treatment. They also considered the potential for allogeneic CAR T cells, new data showing that investigators may be able to cut CAR T development time down to 1 to 2 days, and ways to expand access and address financial toxicity.


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