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Opinion|Videos|March 6, 2026

Toxicity Considerations With ADCs and Other Approaches in EGFR-Mutated NSCLC

Author(s)Joel Neal, MD, PhD, Sarah B. Goldberg, MD, MPH

Joel Neal, MD, PhD, and Sarah Goldberg, MD, MPH, discuss toxicity considerations with ADCs and emerging therapies in EGFR-mutated NSCLC.

Episodes in this series

EP. 1 Factors Driving Frontline Treatment Selection in EGFR-Mutated NSCLC

EP. 1 Factors Driving Frontline Treatment Selection in EGFR-Mutated NSCLC

EP. 2 Navigating Treatment Decisions for EGFR-Mutated NSCLC With High-Risk Features

EP. 2 Navigating Treatment Decisions for EGFR-Mutated NSCLC With High-Risk Features

EP. 3 The Role of Amivantamab Plus Lazertinib in EGFR-Mutated NSCLC Management

EP. 3 The Role of Amivantamab Plus Lazertinib in EGFR-Mutated NSCLC Management

EP. 4 AE Management With Subcutaneous Amivantamab in EGFR-Mutated NSCLC

EP. 4 AE Management With Subcutaneous Amivantamab in EGFR-Mutated NSCLC

EP. 5 How Frontline Therapy Affects Sequencing Considerations in EGFR-Mutated NSCLC

EP. 5 How Frontline Therapy Affects Sequencing Considerations in EGFR-Mutated NSCLC

EP. 6 Toxicity Considerations With ADCs and Other Approaches in EGFR-Mutated NSCLC

EP. 6 Toxicity Considerations With ADCs and Other Approaches in EGFR-Mutated NSCLC

Joel Neal, MD, PhD, and Sarah Goldberg, MD, MPH, review safety considerations associated with antibody-drug conjugates such as datopotamab deruxtecan (Dato-DXd) and other emerging therapies in EGFR-mutated NSCLC. Neal discusses the management of key toxicities associated with Dato-DXd. Goldberg underscores the importance of early recognition and multidisciplinary management to minimize serious adverse outcomes while preserving clinical benefit.

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