Unpacking Data and Upcoming Developments for Olverembatinib in CML

Welcome to OncLive On Air®! I’m your host today, Riley Kandel.

OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we spoke with Elias Jabbour, MD, and Dennis Kim, MD. Dr Jabbour is a professor of Leukemia at The University of Texas MD Anderson Cancer Center in Houston. Dr Kim is an associate professor at the Institute of Medical Science at the University of Toronto in Canada.

In our exclusive interview, Drs Jabbour and Kim discussed the third-generation TKI olverembatinib (HQP1351), how it works, and its advantages compared with other treatment options for chronic myeloid leukemia and acute lymphoblastic leukemia. Additionally, the 2 experts overviewed data for the investigational TKI that came out of the 2026 ASCO Annual Meeting like the phase 1b HQP1351CU101 trial (NCT04260022) and a single-arm, multicenter study (ChiCTR2200061655), as well as the next steps for olverembatinib like in the ongoing phase 3 POLARIS-2 (NCT06423911) trial.

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