Ramsey N. Asmar, MD
The addition of atezolizumab (Tecentriq) to chemotherapy for the frontline treatment of patients with extensive-stage small cell lung cancer (SCLC) significantly prolonged progression-free (PFS) and overall survival (OS) compared with chemotherapy alone, according to phase III data of the IMpower133 trial.
In the study, 403 patients with treatment-naïve SCLC were randomized to receive atezolizumab (n = 201) or placebo (n = 202). At a median follow-up of 13.9 months, the median OS in the atezolizumab group was 12.3 months versus 10.3 months for chemotherapy alone (HR, 0.70; 95% CI, 0.54-0.91; P
= .007). Moreover, median PFS was 5.2 months for patients treated with the combination and 4.3 months in the placebo group.
Patients received carboplatin and etoposide with either atezolizumab or placebo for 4 induction cycles of 21 days, followed by a maintenance phase of the PD-L1 inhibitor or placebo.
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