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Study Identifies Factors Linked to Long-Term Survival in Pediatric/Adolescent DIPG

Jason Harris
Published: Wednesday, May 23, 2018

Maryam Fouladi, MD

Maryam Fouladi, MD
A number of biological factors, including age at diagnosis, symptom duration at diagnosis, and HIST1H3B mutation status, are associated with survival ≥2 years in children and young adults with diffuse intrinsic pontine glioma (DIPG), a brainstem malignancy with a median survival <1 year.

Investigators with the Pediatric Oncology DIPG registries analyzed data collected from 1008 patients in Austria, Australia, Croatia, France, Germany, Italy, the Netherlands, North America, Switzerland, and the United Kingdom. Eligible patients in North America and Australia were aged 0 to 27 years (n = 409), while those in Europe and the United Kingdom were aged 0 to 21 years (n = 721). The median patient age was 6.8 years (range, 0-26.8).

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