VISIT US IN CHICAGO JUNE 2-4 AT BOOTH 2073!

Dr. Brudno on Allogeneic T Cells Expressing an Anti-CD19 CAR in B-Cell Malignancies

Jennifer N. Brudno, MD
Published: Monday, Dec 07, 2015



Jennifer N. Brudno, MD, medical oncology fellow, National Cancer Institute, discusses a study examining allogeneic T cells expressing an anti-CD19 chimeric antigen receptor (CAR), which was found to cause remissions of B-cell malignancies after allogeneic hematopoietic stem cell transplantation, without causing graft-versus-host disease.

The phase I study examined CAR T cells in patients who previously received an allogeneic stem cell transplant for CD19-positive B-cell malignancies who failed on previous therapies. T cells that were manipulated to receive the CAR therapy were derived from donors of stem cell transplants.

This marks the first time this was deemed safe for these patients, and there was also no reports of graft-versus-host disease. Toxicities were similar compared with patients who underwent autologous transplants.

<<< View more from the 2015 ASH Annual Meeting



Jennifer N. Brudno, MD, medical oncology fellow, National Cancer Institute, discusses a study examining allogeneic T cells expressing an anti-CD19 chimeric antigen receptor (CAR), which was found to cause remissions of B-cell malignancies after allogeneic hematopoietic stem cell transplantation, without causing graft-versus-host disease.

The phase I study examined CAR T cells in patients who previously received an allogeneic stem cell transplant for CD19-positive B-cell malignancies who failed on previous therapies. T cells that were manipulated to receive the CAR therapy were derived from donors of stem cell transplants.

This marks the first time this was deemed safe for these patients, and there was also no reports of graft-versus-host disease. Toxicities were similar compared with patients who underwent autologous transplants.

<<< View more from the 2015 ASH Annual Meeting


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections: New York GU™: 10th Annual Interdisciplinary Prostate Cancer Congress® and other Genitourinary MalignanciesMay 30, 20181.5
Community Practice Connections™: Advancing RCC: A Focused Assessment of Recent Paradigm Shifts and Next Steps to Move the Field ForwardMay 30, 20181.5
Publication Bottom Border
Border Publication
x