Advancing Care in Endometrial Cancer: Exploring Long-Term Outcomes and Real-World Evidence

Panelists discuss how advanced/recurrent endometrial cancer has remained a high unmet need due to years of minimal survival gains with carboplatin/paclitaxel until immunotherapy began shifting outcomes.

Panelists discuss how LEAP-001, despite missing primary endpoints, suggested meaningful activity for lenvatinib plus pembrolizumab in dMMR and post-adjuvant subgroups who may need alternatives to standard frontline chemotherapy.

Panelists discuss how comparing LEAP-001, KEYNOTE-775, RUBY, and NRG-GY018 helps position lenvatinib plus pembrolizumab mainly after chemotherapy (or when chemo isn’t feasible) while reinforcing chemo–PD-1 combinations—especially in dMMR disease.

Panelists discuss how DUO-E and AtTEnd broaden options beyond PD-1 approaches, with PD-L1 and PARP–immunotherapy combinations offering promising signals for selected pMMR subgroups amid real-world access and tolerability considerations.

Panelists discuss how emerging 5-year survival data—once rare in this setting—are influencing guideline evolution by increasing confidence in regimens that deliver sustained benefit and informing more nuanced sequencing decisions.

Panelists discuss how trial survival curves show an emerging long-term “tail,” strongest in dMMR disease, and how differences between PD-1 and PD-L1 regimens may reflect mechanism and study-design factors when counseling patients.

Panelists discuss how counseling differs for dMMR versus pMMR disease by framing dMMR as more likely to achieve durable benefit from immunotherapy while presenting pMMR gains as modest but meaningful with potential added options from PARP–IO strategies.

Panelists discuss how proactive management of hypertension, diarrhea, and hypothyroidism—plus dose holds and reductions—helps patients stay on lenvatinib-based therapy long enough to realize benefit.

Panelists discuss how combining controlled trial evidence with real-world experience supports more realistic discussions of prognosis, tolerability, and the value of durable long-term follow-up.

Panelists discuss how real-world use of lenvatinib plus pembrolizumab generally aligns with trial outcomes but often requires individualized dosing, and how post-adjuvant analyses raise interest in earlier-line incorporation while more evidence matures.

Panelists discuss how real-world findings suggest platinum re-challenge offers limited, short-lived benefit in this disease and is often less favorable than newer systemic options after recurrence.

Panelists discuss how future progress depends on better biomarkers (especially within pMMR), smarter sequencing across expanding modalities, and stronger survivorship planning as more patients experience durable control.