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Opinion|Videos|January 2, 2026

Endometrial Cancer: Framing Prognosis, Weaving Clinical Trials and Real-World Data into Patient Conversations

Author(s)Nicoletta Colombo, MD, PhD, David Miller, MD

Panelists discuss how combining controlled trial evidence with real-world experience supports more realistic discussions of prognosis, tolerability, and the value of durable long-term follow-up.

Episodes in this series

2 experts are featured in this series

EP. 1 Endometrial Cancer Today: Defining the Persistent Unmet Needs in Advanced and Recurrent Disease

2 experts are featured in this series

EP. 2 Endometrial Cancer: Interpreting dMMR and Post-Adjuvant Activity from LEAP-001

2 experts are featured in this series

EP. 3 Endometrial Cancer: An Integrated View of LEAP-001, KEYNOTE-775, RUBY and NRG-GY018 for Treatment Strategy

2 experts are featured in this series

EP. 4 Endometrial Cancer: Broadening Therapeutic Options in pMMR - Insights from DUO-E/AtTEnd

2 experts are featured in this series

EP. 5 Endometrial Cancer: How New Long-Term Survival Data Inform Guideline Evolution and Sequencing

2 experts are featured in this series

EP. 6 Endometrial Cancer: Evidence of a Long-Term “Tail” - Comparing PD-1 and PD-L1 Regimens

2 experts are featured in this series

EP. 7 Endometrial Cancer: Counseling on dMMR vs pMMR - Explaining Survival Advantage and Clinical Expectations

2 experts are featured in this series

EP. 8 Endometrial Cancer: Toxicity Management and Treatment Persistence with Lenvatinib-Pembrolizumab

2 experts are featured in this series

EP. 9 Endometrial Cancer: Framing Prognosis, Weaving Clinical Trials and Real-World Data into Patient Conversations

2 experts are featured in this series

EP. 10 Endometrial Cancer: Sequencing Lenvatinib–Pembrolizumab - Alignment with Trials, Post-Adjuvant Potential, and Dose Flexibility

2 experts are featured in this series

EP. 11 Endometrial Cancer: Evaluating Platinum Re-Challenge Strategies Through the ECHO-EU Lens

2 experts are featured in this series

EP. 12 Endometrial Cancer: Future Directions - Biomarkers, Sequencing, and Survivorship Priorities

When discussing long term expectations with patients, clinicians must balance controlled trial data with real world experience. Clinical trials provide high quality evidence to compare treatment options and guide efficacy based decisions, but trial participants often differ from everyday patients in performance status and comorbidity. Real world insights therefore play an essential role in shaping a realistic understanding of tolerability and day to day outcomes.Long term follow up from major trials further enhances these discussions. The presence of durable benefit and clear survival trends helps clinicians speak more confidently about the potential course of disease. Seeing long standing survival curves gives patients a sense of hope and assists clinicians in communicating the value of sustained therapy. Together, trial evidence and real world outcomes provide a balanced and comprehensive foundation for patient counseling.

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