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Dr. Bendell on Remaining Questions With Regorafenib in HCC

Johanna C. Bendell, MD
Published: Friday, Apr 21, 2017



Johanna C. Bendell, MD, director of GI Oncology Research at Sarah Cannon Research Institute, discusses the remaining questions researchers have with regorafenib (Stivarga) for patients with hepatocellular carcinoma (HCC).

The biggest thing with regorafenib, Bendell says, is how to dose it safely and how to limit the associated toxicities that are observed. The current starting dose is 160 mg daily, but if physicians administer that dose they should educate patients about the toxicities. Patients should also report any related adverse events immediately so physicians can hold treatment before it becomes intolerable.

Some practitioners, though, are starting at lower doses, such as 120 mg or even 80 mg, she says.


Johanna C. Bendell, MD, director of GI Oncology Research at Sarah Cannon Research Institute, discusses the remaining questions researchers have with regorafenib (Stivarga) for patients with hepatocellular carcinoma (HCC).

The biggest thing with regorafenib, Bendell says, is how to dose it safely and how to limit the associated toxicities that are observed. The current starting dose is 160 mg daily, but if physicians administer that dose they should educate patients about the toxicities. Patients should also report any related adverse events immediately so physicians can hold treatment before it becomes intolerable.

Some practitioners, though, are starting at lower doses, such as 120 mg or even 80 mg, she says.



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