Dr. Brentjens Discusses Potential for CAR T-Cell Therapy in Solid Tumors

Renier Brentjens, MD, PhD
Published: Wednesday, Jan 24, 2018



Renier Brentjens, MD, PhD, associate professor, chief, Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, discusses the potential for chimeric antigen receptor therapy (CAR) T-cell therapy in solid tumors.

The success of CD19-targeted CAR T-cell therapy has emboldened investigators to look at other targets on solid tumors—which could be the next big breakthrough, Brentjens says. If successful CAR T-cell therapy would live up to the hype that has surrounded it in the larger medical community.

Brentjens says that the field is no longer solely focused on CD19-directed CAR T-cell therapies in lymphoma and leukemia. Expanding to solid malignancies will be challenging, but doable, Brentjens adds.

Current FDA-approved CAR T-cell therapies include tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (axi-cel; Yescarta), the latter of which targets CD19 in hematologic malignancies.
 


Renier Brentjens, MD, PhD, associate professor, chief, Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, discusses the potential for chimeric antigen receptor therapy (CAR) T-cell therapy in solid tumors.

The success of CD19-targeted CAR T-cell therapy has emboldened investigators to look at other targets on solid tumors—which could be the next big breakthrough, Brentjens says. If successful CAR T-cell therapy would live up to the hype that has surrounded it in the larger medical community.

Brentjens says that the field is no longer solely focused on CD19-directed CAR T-cell therapies in lymphoma and leukemia. Expanding to solid malignancies will be challenging, but doable, Brentjens adds.

Current FDA-approved CAR T-cell therapies include tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (axi-cel; Yescarta), the latter of which targets CD19 in hematologic malignancies.
 



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