Dr. Krakow on Genetic Testing in Ovarian Cancer

Deborah Krakow, MD
Published: Wednesday, May 30, 2018



Deborah Krakow, MD, professor and chair, Department of Obstetrics and Gynecology, professor of Orthopaedic Surgery and Human Genetics, University of California, Los Angeles, discusses genetic testing in patients with ovarian cancer.

In terms of genetic testing, Krakow states that if a patient has a family history, a first degree relative with ovarian cancer, or a personal history of either ovarian or breast cancer, they should be tested for the known high-risk genes. If a patient is Ashkenazi Jewish and is diagnosed with ovarian cancer, even without a known family history of breast or ovarian cancer, they should be tested.

Approximately, 1% to 2% of Ashkenazi Jewish women have the same mutation in BRCA1. What is interesting states Krakow, is that all populations report changes in BRCA1/2, so it is not unique to one population. However, it has been enriched in the Ashkenazi Jewish population, confirms Krakow.


Deborah Krakow, MD, professor and chair, Department of Obstetrics and Gynecology, professor of Orthopaedic Surgery and Human Genetics, University of California, Los Angeles, discusses genetic testing in patients with ovarian cancer.

In terms of genetic testing, Krakow states that if a patient has a family history, a first degree relative with ovarian cancer, or a personal history of either ovarian or breast cancer, they should be tested for the known high-risk genes. If a patient is Ashkenazi Jewish and is diagnosed with ovarian cancer, even without a known family history of breast or ovarian cancer, they should be tested.

Approximately, 1% to 2% of Ashkenazi Jewish women have the same mutation in BRCA1. What is interesting states Krakow, is that all populations report changes in BRCA1/2, so it is not unique to one population. However, it has been enriched in the Ashkenazi Jewish population, confirms Krakow.



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