Dr. Maloney on Challenges With CAR T-Cell Therapy in ALL

David G. Maloney, MD, PhD
Published: Monday, Oct 09, 2017



David G. Maloney, MD, PhD, member of the Clinical Research Division, Fred Hutchinson Cancer Research Center in Seattle, Washington, discusses the challenges that exist in the use of chimeric antigen receptor (CAR) T-cell therapy in acute lymphocytic leukemia (ALL).

On August 30, 2017, the FDA approved tisagenlecleucel (Kymriah) for the treatment of patients up to 25 years of age with B-cell precursor ALL that is refractory or in second or later relapse.

Challenges still exist, says Maloney, namely the age cutoff. Studies are now being done conducted in adults, and the toxicities that are being seen are manageable, Maloney adds.
 


David G. Maloney, MD, PhD, member of the Clinical Research Division, Fred Hutchinson Cancer Research Center in Seattle, Washington, discusses the challenges that exist in the use of chimeric antigen receptor (CAR) T-cell therapy in acute lymphocytic leukemia (ALL).

On August 30, 2017, the FDA approved tisagenlecleucel (Kymriah) for the treatment of patients up to 25 years of age with B-cell precursor ALL that is refractory or in second or later relapse.

Challenges still exist, says Maloney, namely the age cutoff. Studies are now being done conducted in adults, and the toxicities that are being seen are manageable, Maloney adds.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Medical Crossfire®: Clinical Updates on PARP Inhibition and its Evolving Use in the Treatment of CancersMay 30, 20181.5
Publication Bottom Border
Border Publication
x