A panel of experts in thoracic oncology discuss the potential impact of recent clinical data on treatment of small cell lung cancer.
EP. 1: First-Line Therapy in ES SCLC: IMpower133
Stephen Liu, MD guides a discussion on recent updates on IO+chemotherapy combinations in extensive-stage small cell lung cancer by reviewing data from the phase 3 IMpower133 l trial of carboplatin/etoposide/atezolizumab.
EP. 2: First-Line Therapy in ES SCLC: CASPIANJuly 15th 2021
Thoracic oncologist, Anne Chiang, MD, PhD, reviews the trial design and results of the CASPIAN trial and emphasizes implications for long-term benefit of combining platinum chemotherapy with durvalumab.
EP. 3: First-Line Therapy in ES SCLS: KEYNOTE-604July 22nd 2021
Key opinion leader in lung cancer, Vivek Subbiah, MD, examines the phase 3 KEYNOTE-604 trial of platinum-based chemotherapy + pembrolizumab and considers whether the data support findings from other trials of chemotherapy + IO combination approaches.
EP. 4: Treatment Considerations: Chemotherapy + IO in ES SCLCJuly 22nd 2021
Panelists reflect on key points from recent studies in ES SCLC by discussing patients for whom immunotherapy may be appropriate, examining the role of adding CTLA4 inhibition to a PD-L1 inhibitor, and reviewing factors to consider when deciding between cisplatin or carboplatin.
EP. 5: Future Directions in ES SCLCJuly 29th 2021
Panelists reflect on treatment considerations for asymptomatic brain metastases, progress in biomarker research, and frequency of administering checkpoint inhibitors.
EP. 6: Treatment After Progression of SCLC: LurbinectedinJuly 29th 2021
Vivek Subbiah, MD, reviews the safety and efficacy of treatment with lurbinectedin in patients who have platinum-sensitive relapsed small cell lung cancer.
EP. 7: Single Agent I/O Therapy for Relapsed/Refractory
Lung cancer expert Anne Chiang, MD, PhD, considers the recent withdrawal of FDA-accelerated approval for nivolumab and pembrolizumab for patients with relapsed extensive-stage small cell lung cancer.
EP. 8: SCLC: Second-Line Options and Supportive Care
Key opinion leaders in thoracic oncology provide insights into second-line treatment for patients with relapsed/refractory small cell lung cancer and comment on the role of trilaciclib in managing cisplatin-associated neutropenia.
EP. 9: SCLC: Rechallenging With Chemotherapy + I/OAugust 12th 2021
Anne Chiang, MD, PhD, renowned expert in thoracic oncology, guides a discussion on whether to rechallenge with chemotherapy + I/O after progression of small cell lung cancer.
EP. 10: Emerging Treatments in SCLC: Bispecific AntibodiesAugust 12th 2021
Expert panelists weigh in on emerging data from recent presentations on small cell lung cancer, including novel immunotherapy approaches such as bispecific antibodies targeting DLL3 or therapies targeting TIGIT.
EP. 11: Emerging Treatments in SCLC: Targeting DNA DamageAugust 19th 2021
Thoracic oncology expert Vivek Subbiah, MD, provides an overview of recent clinical trials studying agents targeting DNA damage for the treatment of small cell lung cancer.
EP. 12: Emerging Treatments in SCLC: Triplets + Limited-Stage DiseaseAugust 19th 2021
Anne Chiang, MD, PhD, reviews the study design of 2 clinical trials, adding a third agent to the standard-of-care regimen of chemotherapy plus I/O; Stephen Liu, MD, discusses clinical trials in limited-stage disease.
EP. 13: Emerging Treatments in SCLC: Impact of Targeted TherapyAugust 26th 2021
Key opinion leaders in lung cancer share personal thoughts on the potential for bispecific agents and the overall impact of inhibiting molecular targets.
EP. 14: Future Directions in Treatment of Small Cell Lung CancerAugust 26th 2021
Panelists conclude their discussion by commenting on areas of unmet need and sharing personal perspectives on factors that may change clinical practice for SCLC in the future.