Shailaja Raj, MD
Purpose: Dendritic cell (DC) vaccines are anticipated as a treatment regimen for the future in the management of solid tumors. Previously we have shown that DC-based vaccines show a consistent immune response, safety, and long-term survival with neoadjuvant radiation.
Tumor heterogeneity, high grade, and larger tumors portend a poor prognosis in soft tissue sarcomas.1,2 In particular chemotherapy, radiation, and surgery, have not succeeded in establishing remission in these patients where comorbidities and older age may be risk factors as well.3,4,5,6,7,8 Therefore, tumor vaccines may be ideal in this population due to their favorable toxicity profile.
... to read the full story