University of Chicago Comprehensive Cancer Center
For nearly 40 years, the University of Chicago (UChicago) Comprehensive Cancer Center (UCCCC) has enjoyed a reputation for excellence and innovation, with more than 200 basic and physician scientists collaborating on research aimed at transforming cancer prevention, screening, and treatment. UCCCC researchers have pioneered studies in a broad range of areas, including the molecular genetics of cancer, cancer immunology, bone marrow transplantation, hormone therapy, and advanced imaging techniques.
Genomic Prescribing: The 1200 Patients Project
Initiated at UChicago, and the flagship project of the newly created Center for Personalized Therapeutics directed by Mark J. Ratain, MD, the 1200 Patients Project is examining the feasibility and potential benefits of using a patient’s genetic information to guide pharmacologic treatment decisions and develop personalized therapeutics throughout his or her lifetime. The study was initiated in January 2011 and by April 2012 had enrolled more than 700 of an anticipated 1200 UChicago outpatients.
Peter H. O’Donnell, MD
Upon enrollment in this first-of-its-kind, 3-year study, each patient submits a single blood sample that is tested for all published genetic markers that might predict response to hundreds of drugs, as well as the likelihood of adverse effects. Patient-specific results will then be made available to study-participating physicians, who will be monitored to determine whether they use the information in decisions about medicine selection or dosing, O’Donnell explained.