Distinct Strategies Needed for Treating Lobular Breast Cancer

Anita T. Shaffer @Shaffer1
Published: Wednesday, Apr 29, 2015
Dr. Jennifer Yuchen Shih

Jennifer Yuchen Shih, MD, MS

Although patients with invasive lobular carcinoma (ILC) are typically treated with the same therapeutic strategies as those with infiltrating ductal malignancies, ILC is emerging as a molecularly complex and distinct tumor type that suggests different approaches may be effective.

Table. Genomic Alterations in Invasive Lobular Cancer Subtypes3

Table. Genomic Alterations in ILC Subtypes3

ER indicates estrogen receptor.

“The genomic analyses show that invasive lobular cancers have more mutations in the PI3 kinase pathway—AKT foci, or the ERBB2/ERBB3,” said Shih. “These mutations are potential treatment targets in the future. There are investigations going on right now using AKT pathway inhibitors and other inhibitors that could potentially work better in this type of breast cancer than in other types for that reason.”

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