Second Relapse Common After Initial Melanoma Recurrence on Adjuvant PD-1 Inhibition

Wayne Kuznar
Published: Thursday, Jun 13, 2019
Despite local therapy, many patients with locoregional recurrence of melanoma during or after adjuvant anti–PD-1 therapy relapse again. Moreover, the benefit of second-line adjuvant treatment in this group of patients is unclear.

In reviewing the entire group of 83 patients who received systemic therapy, 29% had subsequent progression and 20 (24%) patients died. At a median follow-up of 7.2 months, the median overall survival from first systemic therapy was 21.3 months.
Owen CN, Larkin JMG, Shoushtari AN, et al. A multicenter analysis of melanoma recurrence following adjuvant anti-PD1 therapy. J Clin Oncol. 2019;37(suppl; abstr 9502).

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