BCL-2: Mechanisms and Prevalence

Published: Thursday, Jan 10, 2019
Every day, the average adult loses approximately 60 billion cells due to apoptosis.1 Although apoptosis facilitates the cellular turnover that is required to maintain homeostasis and plays important roles in development, misregulated apoptotic processes can contribute to disease. Indeed, a disruption of the balance between cell death and proliferation is a feature of many cancers. Apoptosis is controlled by a tightly regulated process that is conserved across metazoans and involves proteins related to the B-cell lymphoma 2 (BCL-2) family. Characterization of the BCL2 oncogene and the BCL-2 protein family led to the current appreciation of the significant role that apoptosis plays in many types of malignancies. This understanding has motivated the current advancements in cancer therapeutics that target different members of apoptotic regulatory networks.

 

Figure. The BCL-2 Protein Family4

FIGURE. The BCL-2 Protein Family

Known helical and transmembrane regions are indicated, as well as BH domains 1-4.

Figure reprinted with open access from Adams JM, Cory S. Cell Death Differ. 2018;25(1):27-36.

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