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|Videos|July 13, 2022

Acute Lymphocytic Leukemia Trial Data From the ASCO 2022 and EHA 2022 Annual Meetings

Author(s)Kieron Dunleavy, MD, Jae H. Park, MD, Elias Jabbour, MD

Expert oncologist perspectives on key clinical trial data in acute lymphocytic leukemia from the ASCO 2022 and EHA 2022 Annual Meetings.

Episodes in this series

Experts on leukemia and lymphoma

EP. 1 Acute Lymphocytic Leukemia Trial Data From the ASCO 2022 and EHA 2022 Annual Meetings

Experts on leukemia and lymphoma

EP. 2 Lymphomas Trial Data From the ASCO 2022 and EHA 2022 Annual Meetings

Data from the following clinical trials are discussed:

ASCO 7009: A phase II trial of a chemotherapy-free combination of ponatinib and blinatumomab in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
ASCO e19003: A phase 1b study of blinatumomab with the anti-programmed cell death (PD)-1 antibody AMG 404 in adults with relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (ALL)
ASCO 7034: A phase II study of hyper-CVAD with sequential blinatumomab (Blina), with or without inotuzumab ozogamicin (INO), in adults with newly diagnosed B-cell acute lymphoblastic leukemia (ALL)
ASCO 7011: Updated results from a phase II study of mini-hyper-CVD (mini-HCVD) plus inotuzumab ozogamicin (INO), with or without blinatumomab (Blina), in older adults with newly diagnosed Philadelphia chromosome (Ph)-negative B-cell acute lymphoblastic leukemia (ALL)
EHA P353: Forty Months of the Gimema LAL2116 (D-ALBA) Protocol and Ancillary LAL2217 Study for Newly Diagnosed Adult PH+ ALL
EHA P366: Blinatumomab Added to Prephase and Consolidation Therapy in Newly Diagnosed Precursor B-ALL in Adults. A Phase II Hovon Trial
EHA PB1762: Ponatinib Versus Imatinib with Reduced – Intensity Chemotherapy in Patients with Newly Diagnosed Philadelphia Chromosone-Positive (PH+) Acute Lymphoblastic Leukemia (ALL): PHALLCON Study
EHA PB1749: Apoptotic Effect of Flumatinib Combined with BCL2 Inhibitor on PH+ B-Cell Acute Lymphoblastic Leukemia

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