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Opinion|Videos|February 21, 2025

Advancing Myelofibrosis Treatment: Personalized Strategies with Fedratinib and Ruxolitinib

Author(s)Andrew Kuykendall, MD, Naseema Gangat, MBBS , Claire Harrison, MD, FRCP, FRCPath

Panelists discuss data from the FREEDOM2 trial and its sub-analysis on low platelet count with fedratinib (FEDR), as well as the pooled analysis of the COMFORT-I/-II trials on ruxolitinib (RUX) for myelofibrosis.

Episodes in this series

EP. 1 Initial Treatment Strategies for Polycythemia Vera

EP. 1 Initial Treatment Strategies for Polycythemia Vera

EP. 2 Cytoreductive Therapy in PV Treatment Paradigm

EP. 2 Cytoreductive Therapy in PV Treatment Paradigm

EP. 3 JAK Inhibition in Polycythemia Vera: Treatment Updates

EP. 3 JAK Inhibition in Polycythemia Vera: Treatment Updates

EP. 4 Interferon Therapy in PV

EP. 4 Interferon Therapy in PV

EP. 5 Safety Considerations for PV Therapy

EP. 5 Safety Considerations for PV Therapy

EP. 6 Evolving Treatment Strategies in Polycythemia Vera: Insights Ffrom Trials and Real-World Evidence

EP. 6 Evolving Treatment Strategies in Polycythemia Vera: Insights Ffrom Trials and Real-World Evidence

EP. 7 Interferon Real- World Treatment Patterns in PV

EP. 7 Interferon Real- World Treatment Patterns in PV

EP. 8 Considerations for Polycythemia Vera Management: Patient Monitoring, Outcomes, and Risks

EP. 8 Considerations for Polycythemia Vera Management: Patient Monitoring, Outcomes, and Risks

EP. 9 Future Considerations for Polycythemia Vera Management: Takeaways from ASH 2024

EP. 9 Future Considerations for Polycythemia Vera Management: Takeaways from ASH 2024

EP. 10 An Overview to Myelofibrosis and Disease Risk

EP. 10 An Overview to Myelofibrosis and Disease Risk

EP. 11 Treatment Goals for Myelofibrosis

EP. 11 Treatment Goals for Myelofibrosis

EP. 12 Personalizing Therapy in Myelofibrosis: Insights from Key Clinical Trials

EP. 12 Personalizing Therapy in Myelofibrosis: Insights from Key Clinical Trials

EP. 13 Advancing Myelofibrosis Treatment: Personalized Strategies with Fedratinib and Ruxolitinib

EP. 13 Advancing Myelofibrosis Treatment: Personalized Strategies with Fedratinib and Ruxolitinib

EP. 14 Real-World Data in Myelofibrosis: Bridging the Gap Between Clinical Trials and Practice

EP. 14 Real-World Data in Myelofibrosis: Bridging the Gap Between Clinical Trials and Practice

EP. 15 Navigating Therapy Challenges in Myelofibrosis: Anemia Management and Disease-Specific Approaches

EP. 15 Navigating Therapy Challenges in Myelofibrosis: Anemia Management and Disease-Specific Approaches

EP. 16 Myelofibrosis at ASH 2024: Key Updates and Emerging Therapies

EP. 16 Myelofibrosis at ASH 2024: Key Updates and Emerging Therapies

EP. 17 MPN Milestones of 2024 and What’s Next for 2025

EP. 17 MPN Milestones of 2024 and What’s Next for 2025

Video content above is prompted by the following:

• Dr Harrison: Fedratinib (FEDR) - FREEDOM2
o FFREEDOM2, Sub-analysis on low plt count
• Dr Gangat: RUX, COMFORT-I/-II Pooled Analysis

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