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Opinion|Videos|June 25, 2024

Assessing HER2 Status Across Tumor Types

Author(s)Vijayakrishna Gadi, MD, University of Illinois College of Medicine, Susana Campos, MD, MPH, Matthew D. Galsky, MD

Dr Gadi leads a discussion surrounding HER2 mutation and overexpression across various cancer types.

Episodes in this series

EP. 1 Assessing HER2 Status Across Tumor Types

EP. 1 Assessing HER2 Status Across Tumor Types

EP. 2 ADCs Targeting HER2+ Breast Cancer

EP. 2 ADCs Targeting HER2+ Breast Cancer

EP. 3 ADCs Targeting HER2+ Gynecologic Cancers

EP. 3 ADCs Targeting HER2+ Gynecologic Cancers

EP. 4 Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP. 4 Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP. 5 ADCs Targeting GI Cancers

EP. 5 ADCs Targeting GI Cancers

EP. 6 ADCs Targeting HER2+ Lung Cancer

EP. 6 ADCs Targeting HER2+ Lung Cancer

EP. 7 Impact of ADCs on Brain Metastases

EP. 7 Impact of ADCs on Brain Metastases

EP. 8 ADCs Targeting HER2+ GU Cancers

EP. 8 ADCs Targeting HER2+ GU Cancers

EP. 9 Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP. 9 Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP. 10 The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP. 10 The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP. 11 Managing ILD and Pneumonitis Risk From ADCs

EP. 11 Managing ILD and Pneumonitis Risk From ADCs

EP. 12 Managing Toxicities in Short- and Long-Term Treatment with ADCs

EP. 12 Managing Toxicities in Short- and Long-Term Treatment with ADCs

A panel of 5 experts on ADCs

EP. 13 Managing Hematologic AEs Associated with ADC Treatments

A panel of 5 experts on ADCs

EP. 14 Management of Emetogenicity of Antibody-Drug Conjugates

A panel of 5 experts on ADCs

EP. 15 ADC Sequencing

A panel of 5 experts on ADCs

EP. 16 Emerging ADCs in Development

EP. 17 Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP. 17 Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP. 18 The Future for HER2-Directed ADCs

EP. 18 The Future for HER2-Directed ADCs

A panel of 5 experts on ADCs

EP. 19 Key Takeaways and Closing Thoughts on ADCs

Video content above is prompted by the following:

How do HER2 mutations differ from HER2 overexpression and gene amplification in terms of their impact on cancer?
- How can this differ among cancer types?
What are the incidences of HER2 overexpression across solid tumors? HER2 mutations?
What is your current practice for testing for HER2? What testing methodologies are used? How do they differ and what can you learn from each?
- What is the difference between HER2 amplification and IHC score? What are best practices to ensure patients with HER2 amplification aren’t missed?
- Does this vary among solid tumors?
- How have levels of HER2 expression changed? What percent of patients typically have HER2-low expression?
Is what is known about HER2 expression/mutations from research in breast and other cancer types applicable to other solid tumor types? Are there unique aspects to consider?
How might current understanding of HER2 expression and HER2 mutations in other solid tumors contribute to the development of future targeted therapies or personalized treatment approaches?

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