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Opinion|Videos|July 12, 2024

Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

Author(s)Vijayakrishna Gadi, MD, University of Illinois College of Medicine, Susana Campos, MD, MPH, Matthew D. Galsky, MD

Dr Gadi leads a discussion on recent data on the treatment of HER2-low tumors, including ASCO updates on the DESTINY-Breast06 trial.

Episodes in this series

EP. 1 Assessing HER2 Status Across Tumor Types

EP. 1 Assessing HER2 Status Across Tumor Types

EP. 2 ADCs Targeting HER2+ Breast Cancer

EP. 2 ADCs Targeting HER2+ Breast Cancer

EP. 3 ADCs Targeting HER2+ Gynecologic Cancers

EP. 3 ADCs Targeting HER2+ Gynecologic Cancers

EP. 4 Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP. 4 Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP. 5 ADCs Targeting GI Cancers

EP. 5 ADCs Targeting GI Cancers

EP. 6 ADCs Targeting HER2+ Lung Cancer

EP. 6 ADCs Targeting HER2+ Lung Cancer

EP. 7 Impact of ADCs on Brain Metastases

EP. 7 Impact of ADCs on Brain Metastases

EP. 8 ADCs Targeting HER2+ GU Cancers

EP. 8 ADCs Targeting HER2+ GU Cancers

EP. 9 Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP. 9 Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP. 10 The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP. 10 The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP. 11 Managing ILD and Pneumonitis Risk From ADCs

EP. 11 Managing ILD and Pneumonitis Risk From ADCs

EP. 12 Managing Toxicities in Short- and Long-Term Treatment with ADCs

EP. 12 Managing Toxicities in Short- and Long-Term Treatment with ADCs

A panel of 5 experts on ADCs

EP. 13 Managing Hematologic AEs Associated with ADC Treatments

A panel of 5 experts on ADCs

EP. 14 Management of Emetogenicity of Antibody-Drug Conjugates

A panel of 5 experts on ADCs

EP. 15 ADC Sequencing

A panel of 5 experts on ADCs

EP. 16 Emerging ADCs in Development

EP. 17 Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP. 17 Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP. 18 The Future for HER2-Directed ADCs

EP. 18 The Future for HER2-Directed ADCs

A panel of 5 experts on ADCs

EP. 19 Key Takeaways and Closing Thoughts on ADCs

Video content above is prompted by the following:

Can you please offer an overview of the primary results from the DESTINY-PanTumor02 trial (Meric-Bernstam_J Clin Oncol_2024), specifically in regard to each of the following:
- cervical
- ovarian cancers
- endometrial
  - STATICE trial results (Nishikawa J Clin Oncol 2023)
  - What is the potential for DB-1303 in endometrial cancer (Moore_J Clin Oncol_2023)
Where in the treatment sequencing do you expect HER2-direct ADCs to fit?

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