Video

CAR T-Cell Therapy’s Future for Lymphoma

Transcript:

Stephen J. Schuster, MD: The next issue is an in-depth analysis of the future directions, and any data that are driving those future directions, anything that you guys saw that was exciting between the last ASH [American Society of Hematology annual meeting] and the current ASCO [American Society of Clinical Oncology] meeting?

What I thought was exciting was that they didn’t use chemotherapy. I’ll bet you don’t see the same kind of cytopenias when you don’t give Cy/Flu [cyclophosphamide, fludarabine]. I’m speaking as somebody who also has seen a lot of CLL [chronic lymphocytic leukemia] in my life, and I’m sure Loretta has seen a lot of CLL where she lives. And [cyclophosphamide, fludarabine] is tough on patients, particularly if they’ve had other prior treatments, including transplants. And I’m not at all surprised that there are prolonged cytopenias. Yes, there’s some impact of having an inflammatory state, particularly if the disease involved the marrow. That’s going to contribute. But believe me, [cyclophosphamide, fludarabine] is not vitamin B12.

Loretta J. Nastoupil, MD: The other thing I thought was interesting about that abstract is they had very low rates of grade 3 or higher CRS [cytokine release syndrome] or neurotoxicity, strikingly low.

Stephen J. Schuster, MD: In some data I’ve seen using the tandem bispecific CAR [chimeric antigen receptor] is similar. I don’t know what to make of that, Loretta, history being important. But that struck me as well.

Transcript Edited for Clarity

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
(CME Track) Clinical Consultations™: Framing a New Approach to Geographic Atrophy Management – Expert Insights into Recent Developments
Video

(CME Track) Clinical Consultations™: Framing a New Approach to Geographic Atrophy Management – Expert Insights into Recent Developments

Apr 23rd 2025 - Apr 24th 2026

online-activity
Optimizing Today and Looking to Tomorrow in Metastatic CRPC—Homing in on EZH2
Video

Optimizing Today and Looking to Tomorrow in Metastatic CRPC—Homing in on EZH2

Apr 23rd 2025 - Apr 24th 2026

online-activity
Addressing Unmet Needs in HER2+ Metastatic BTC
Video

Addressing Unmet Needs in HER2+ Metastatic BTC

Apr 18th 2025 - Apr 19th 2026

online-activity