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Opinion|Videos|January 26, 2026

Clinical Insights From the TROPION Lung Studies

Author(s)Benjamin P. Levy, MD, David L. Rimm, MD, PhD

Recent studies on Trop2-ADC reveal promising predictive biomarkers for lung cancer treatment, sparking excitement while urging caution for further research.

Episodes in this series

EP. 1 The Role of TROP2 in Non-Small Cell Lung Cancer

EP. 1 The Role of TROP2 in Non-Small Cell Lung Cancer

EP. 2 Limitations of Conventional Immunohistochemistry for TROP2 Assessment

EP. 2 Limitations of Conventional Immunohistochemistry for TROP2 Assessment

EP. 3 Quantitative Continuous Scoring as an Approach to TROP2 Measurement

EP. 3 Quantitative Continuous Scoring as an Approach to TROP2 Measurement

EP. 4 Clinical Insights From the TROPION Lung Studies

EP. 4 Clinical Insights From the TROPION Lung Studies

EP. 5 Future Directions for Validating TROP2 Biomarkers in Lung Cancer

EP. 5 Future Directions for Validating TROP2 Biomarkers in Lung Cancer

Dr. Levy reviews clinical evidence while Dr. Rimm provides biomarker context as they examine retrospective analyses from TROPION Lung studies evaluating TROP2 normalized membrane ratio. Dr. Levy summarizes findings showing that TROP2 NMR distinguished patients who derived greater benefit from TROP2-directed antibody drug conjugates, while no such distinction was observed in chemotherapy control arms. Together, they emphasize that these results suggest a predictive rather than prognostic role for the biomarker. Additional early data from frontline combination studies are discussed, reinforcing the hypothesis that quantitative TROP2 assessment may help identify patients more likely to respond to these therapies. Both experts stress that the findings remain exploratory and derived from small subsets, underscoring the importance of cautious interpretation and the need for prospective confirmation.

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