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Opinion|Videos|January 26, 2026

Future Directions for Validating TROP2 Biomarkers in Lung Cancer

Author(s)Benjamin P. Levy, MD, David L. Rimm, MD, PhD

Explore the evolving role of Trop-2 in non-small cell lung cancer and the importance of larger studies and biomarkers for future treatments.

Episodes in this series

EP. 1 The Role of TROP2 in Non-Small Cell Lung Cancer

EP. 1 The Role of TROP2 in Non-Small Cell Lung Cancer

EP. 2 Limitations of Conventional Immunohistochemistry for TROP2 Assessment

EP. 2 Limitations of Conventional Immunohistochemistry for TROP2 Assessment

EP. 3 Quantitative Continuous Scoring as an Approach to TROP2 Measurement

EP. 3 Quantitative Continuous Scoring as an Approach to TROP2 Measurement

EP. 4 Clinical Insights From the TROPION Lung Studies

EP. 4 Clinical Insights From the TROPION Lung Studies

EP. 5 Future Directions for Validating TROP2 Biomarkers in Lung Cancer

EP. 5 Future Directions for Validating TROP2 Biomarkers in Lung Cancer

Drs. Levy and Rimm conclude by discussing what is needed to validate TROP2 biomarkers for routine clinical use. Their conversation focuses on the importance of larger datasets, prospective trial designs, and systematic evaluation of multiple quantitative variables rather than reliance on a single metric. Dr. Rimm highlights the value of further analyzing existing trial data to identify the most robust and reproducible predictors of response, while Dr. Levy outlines how upcoming phase III studies may help clarify the clinical utility of TROP2 measurement. Both emphasize that prospective validation is essential before adoption in everyday practice. The discussion closes by reinforcing the shared goal of delivering the right drug to the right patient and positioning quantitative biomarker measurement as a critical step toward more precise treatment selection in lung cancer.

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