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Opinion|Videos|February 6, 2026

Pharmacy-Led Strategies for Early Diarrhea Management in HR+/HER2-Negative Advanced Breast Cancer

Author(s)Dr. Neil Iyengar, MD, Heather Moore, CPP, PharmD, Sarah Donahue, MPH, NP, AOCNP

Learn effective strategies for counseling patients on managing diarrhea when initiating PI3 kinase or AKT pathway inhibitors.

Episodes in this series

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EP. 1 Patient Identification and Molecular Testing in HR+/HER2-Negative Advanced Breast Cancer

Experts featured in this series.

EP. 2 Baseline Patient Education for Diarrhea Prevention in HR+/HER2-Negative Advanced Breast Cancer

Experts featured in this series.

EP. 3 Pharmacy-Led Strategies for Early Diarrhea Management in HR+/HER2-Negative Advanced Breast Cancer

Experts featured in this series.

EP. 4 Clinical Assessment and Pharmacologic Considerations for Diarrhea Management in HR+/HER2-Negative Advanced Breast Cancer

In this segment, Dr. Neil Iyengar moderates a pharmacy-focused discussion with Heather Moore, CPP, PharmD on proactive strategies to manage early-onset diarrhea associated with PI3K and AKT pathway inhibitors in HR+/HER2-negative advanced breast cancer. Ms. Moore outlines how pharmacists play a key role at treatment initiation by setting expectations for gastrointestinal adverse events and ensuring patients are equipped with supportive medications before symptoms arise. The discussion highlights early use of antidiarrheal agents, clear instructions on dosing and escalation, and reinforcement of hydration and dietary guidance. Ms. Moore also emphasizes the importance of reviewing concomitant medications and comorbidities that may exacerbate diarrhea risk. The segment underscores how early pharmacy engagement helps standardize supportive care, reduces delays in symptom management, and supports adherence by preventing diarrhea from becoming severe or treatment limiting. This conversation illustrates the value o

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