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Opinion|Videos|January 30, 2026

Baseline Patient Education for Diarrhea Prevention in HR+/HER2-Negative Advanced Breast Cancer

Author(s)Dr. Neil Iyengar, MD, Heather Moore, CPP, PharmD, Sarah Donahue, MPH, NP, AOCNP

Explore expert insights on managing adverse events in advanced breast cancer treatments targeting the PI3 Kinase/AKT/PTEN pathway.

Episodes in this series

Experts featured in this series.

EP. 1 Patient Identification and Molecular Testing in HR+/HER2-Negative Advanced Breast Cancer

Experts featured in this series.

EP. 2 Baseline Patient Education for Diarrhea Prevention in HR+/HER2-Negative Advanced Breast Cancer

In this segment, Dr. Neil Iyengar moderates a focused discussion with Sarah Donahue, MPH, NP, AOCNP on the importance of baseline patient education when initiating PI3K or AKT pathway inhibitors in HR+/HER2-negative advanced breast cancer.

The conversation highlights how early education around expected gastrointestinal adverse events, including diarrhea, can support prompt symptom recognition and timely intervention. Ms. Donahue discusses practical counseling strategies related to hydration, dietary modifications, and clear guidance on when patients should contact the care team.

The discussion also emphasizes the need to individualize education for older adults and more medically fragile patients by simplifying instructions, reinforcing follow-up plans, and engaging caregivers when appropriate. This segment underscores how proactive, patient-centered education is a critical first step in reducing the severity of diarrhea, supporting adherence, and improving overall treatment tolerance.

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