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Opinion|Videos|January 30, 2026

Patient Identification and Molecular Testing in HR+/HER2-Negative Advanced Breast Cancer

Author(s)Dr. Neil Iyengar, MD, Heather Moore, CPP, PharmD, Sarah Donahue, MPH, NP, AOCNP

Explore expert insights on managing adverse events in advanced breast cancer treatments targeting the PI3 Kinase/AKT/PTEN pathway.

Episodes in this series

Experts featured in this series.

EP. 1 Patient Identification and Molecular Testing in HR+/HER2-Negative Advanced Breast Cancer

Experts featured in this series.

EP. 2 Baseline Patient Education for Diarrhea Prevention in HR+/HER2-Negative Advanced Breast Cancer

In this opening segment, the panel provides clinical context for how patients with HR+/HER2-negative advanced breast cancer are identified for therapies targeting the PI3K/AKT/PTEN pathway. Dr. Iyengar moderates a high-level discussion focused on the role of comprehensive genomic testing in contemporary practice, emphasizing the importance of identifying actionable alterations such as PIK3CA, AKT1, and PTEN.

The panelists discuss when molecular testing is typically performed in the disease course, including the use of tumor tissue and liquid biopsy approaches, and how results inform treatment planning beyond first-line endocrine-based therapy. The conversation highlights real-world considerations such as repeat testing at progression, integration of next-generation sequencing into routine workflows, and the need to align molecular findings with evolving targeted treatment options.

This segment establishes the biologic and diagnostic foundation that underpins subsequent discussions on adverse event management within the PI3K/AKT/PTEN pathway in advanced breast cancer.

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